Table 1.
Summary of histological findings
| Number of SGCs | Mean±SD | P1 | P2 | P3 | P4 | P5 | P6 |
|---|---|---|---|---|---|---|---|
| Normal Hearing | 39.4±7.8 | 51.5 | 41.9 | 38.6 | 34.7 | 34.2 | 33.3 |
| Deafened Control | 7.4±2.9 | 7.8 | 6.0 | 7.0 | 7.1 | 8.5 | 8.2 |
| Low dose AO 1mg/kg/day Trolox and 20mg/kg/day ascorbic acid | 13.5± 3.5 | 19.1 | 10.6 | 12.5 | 12.7 | 12.6 | 13.2 |
| High dose AO 10mg/kg/day Trolox and 200mg/kg/day ascorbic acid | 17.7± 7.3 | 22.8 | 12.7 | 15.7 | 18.5 | 18.5 | 17.7 |
| Area | Mean±SD | P1 | P2 | P3 | P4 | P5 | P6 |
|
| |||||||
| Normal Hearing | 49387±6463 | 70974 | 51336 | 45799 | 42123 | 41561 | 41260 |
| Deafened Control | 51325±4726 | 66460 | 56893 | 47988 | 46843 | 40387 | 53710 |
| Low dose AO 1mg/kg/day Trolox and 20mg/kg/day ascorbic acid | 56023±4626 | 82663 | 57639 | 50511 | 47574 | 43017 | 54734 |
| High dose AO 10mg/kg/day Trolox and 200mg/kg/day ascorbic acid | 53560±4260 | 84010 | 55141 | 50258 | 43780 | 41698 | 46470 |
| Density | Mean±SD | P1 | P2 | P3 | P4 | P5 | P6 |
|
| |||||||
| Normal Hearing | 7.9±0.5 | 6.3 | 8.2 | 8.5 | 8.4 | 8.2 | 8.1 |
| Deafened Control | 1.5±0.5 | 1.0 | 1.0 | 1.5 | 1.5 | 2.1 | 1.4 |
| Low dose AO 1mg/kg/day Trolox and 20mg/kg/day ascorbic acid | 2.5±0.7 | 2.3 | 1.8 | 2.5 | 2.7 | 3.0 | 2.5 |
| High dose AO 10mg/kg/day Trolox and 200mg/kg/day ascorbic acid | 3.5±1.6 | 2.9 | 2.3 | 3.2 | 4.3 | 4.5 | 4.1 |
AO: antioxidants Trolox and ascorbic acid. For each value of SGC number and area of Rosenthal’s canal 6 sections were evaluated at each site along the cochlea (P1 – P6) times an n = 8 animals in each group: Normal, Deaf-untreated, Deaf-low dose AO treated, & Deaf- high dose AO treated.