Figure 3.

SNARE-syntaxin network expanded by predicted interactions. Proteins with known, experimentally determined interactions (blue lines) from the BIND dataset formed an initial set. This was expanded one layer outwards by identifying all proteins that are predicted to interact with proteins from the initial set. All predicted interactions are rated by CV (line thickness) and coexpression (line color). Nodes are color coded with predicted subcellular localizations and sized according to the number of predicted interacting protein partners throughout the entire predicted interactome. Note that the interaction between OSM1 and VTI12 is both predicted and experimentally determined (both red and blue lines connect these nodes).