Figure 5.

Coexpression of interologs. A, The PCC for 19,979 predicted interaction pairs was calculated and plotted as the number of pairs in each Pearson correlation coefficient range, with an r unit bin size of 0.1 (blue points). The correlation coefficient calculation was also performed for 20,000 randomly selected pairs of Arabidopsis genes from within our interactome (green points), from all AGI IDs on the ATH1 GeneChip (red points), or from all AGI IDs on the ATH1 GeneChip such that the topology of the random network was the same as that of our predicted interactome (magenta points). Note that not all gene pairs mapped to probe sets on the Affymetrix ATH1 Gene Chip. The gene expression set used is an compendium of the four smaller AtGenExpress compendia displayed in the Expression Browser tool at http://bbc.botany.utoronto.ca. These include data sets generated by Schmid et al. (2005), Kilian et al. (2007), and other members of the AtGenExpress consortium. Genes with a high PCC are considered to be coexpressed. The interolog distribution is shown to contain many coexpressed pairs. B, The interolog CV was plotted against the correlation coefficient for each pair, demonstrating that a high confidence score (score ≥ 11) may suggest that the interolog pair is coexpressed. Significant values (P < 0.05) lie above and below the dotted lines. [See online article for color version of this figure.]