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Possible role of AtREV1 in polymerase switching. A, Replication-type polymerase (white oval) bound to PCNA (gray ring) is stalled at the damage. B, PCNA is monoubiquitinated (Ub), which increases its affinity for AtREV1 (black oval with pocket that represents the UBM). C, TLS-type polymerase (hatched oval) interacts with the PCNA-bound AtREV1. D, A nucleotide (black square) is inserted by the action of the TLS-type polymerase. See the text for more detail.
