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. Author manuscript; available in PMC: 2008 Oct 1.
Published in final edited form as: J Surg Res. 2007 Jul 13;142(2):332–340. doi: 10.1016/j.jss.2007.05.033

Figure 6.

Figure 6

Figure 6

Figure 6

Figure 6

Figure 6

A A comparison of the effect of pluronic gel with and without PD98059 (PD), SB230580 (SB) and SP600125 (SP) on intimal hyperplasia development at 14 days after wire injury. Values are the Mean± s.e.m of the intima:media area ratio (n=6 per group).. Statistical differences between groups were tested with a Kruskal-Wallis non-parametric test with post hoc Dunn’s multiple comparison correction, where appropriate. A p-value less than 0.05 was regarded as significant. Non-significant p-values were expressed as p=ns

B The effect of pluronic gel with and without PD98059 (PD), SB230580 (SB) and SP600125 (SP) on maximal kinase activation for ERK1/2, p38MAPK and JNK. All data are presented as the mean ± s.e.m. (n=6 per group). and statistical differences between groups were tested with a Kruskal-Wallis non-parametric test with post hoc Dunn’s multiple comparison correction, where appropriate.

C Changes in cell proliferation, cell apoptosis and cell migration in wire injured femoral vessels in the presence of pluronic gel with and without PD98059 (PD), SB230580 (SB) and SP600125 (SP). Values are the mean± s.e.m. (n=6 per group). Statistical differences between groups were tested with a Kruskal-Wallis non-parametric test with post hoc Dunn’s multiple comparison correction, where appropriate.

D /E Alterations in the expression (D) and activity (E) of uPA and PAI-1 in wire injured femoral vessels in the presence of pluronic gel with and without PD98059 (PD), SB230580 (SB) and SP600125 (SP). Values are the mean± s.e.m. (n=6 per group). Statistical differences between groups were tested with a Kruskal-Wallis non-parametric test with post hoc Dunn’s multiple comparison correction, where appropriate.