TABLE 3.

Neutralizing Potential of MAbs

	IC50 Neutralization titer (μg/ml)a
Isolate	P1H6 (V1)	P3C8 (V1)	P3B2 (V1)	P4D7 (V1)	P3E1 (V3)	P3C5 (V3)	447-52D (V3)	P1G9 (cluster I)	P2D2 (C-HR)	P3G9 (gp41)	P4A3 (gp41)	P4C2 (gp41)	2F5 (MPER)
SF162	0.3	0.6	1.0	0.8	0.2	16.0	0.2c	-	-	-	-	-	1.0c
ΔV1	-b	-	-	-	4.0	-	1c	-	-	-	-	-	2.0c
ΔV2	0.003	0.003	0.01	0.08	<0.001	1.0	0.01c	-	-	25.0	-	-	<0.01c
ADA	-	-	-	-	-	-	-	-	-	-	-	-	nd
ADA/SF162 V1	ndd	nd	nd	nd	-	nd	-	nd	nd	nd	nd	nd	nd
JRFL	-	-	-	-	-	-	15.0	-	-	-	-	-	nd
JRFL/SF162 V1	nd	nd	nd	nd	10	nd	1.5	nd	nd	nd	nd	nd	nd
YU2	-	-	-	-	-	-	-	-	-	-	-	-	nd
YU2/SF162 V1	nd	nd	nd	nd	-	nd	2.0	nd	nd	nd	nd	nd	nd
HxB2	-	-	-	-	-	-	0.2	-	-	-	-	-	nd
HxB2/SF162 V1	nd	nd	nd	nd	-	nd	0.01	nd	nd	nd	nd	nd	nd
89.6	-	-	-	-	6.0	-	0.001	-	-	-	-	-	nd
89.6/SF162 V1	nd	nd	nd	nd	0.1	nd	<0.001	nd	nd	nd	nd	nd	nd
SS1196.01	-	-	-	-	3.5	-	nd	nd	nd	nd	nd	nd	nd
6535.3	-	-	-	-	16.5	-	nd	nd	nd	nd	nd	nd	nd
7165.18	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
6101.1	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
QH0692.42	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
QH0515.1	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
AC10.0.29	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
PVO.4	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
TRO.11	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
5768.4	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
3988.25	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd
BG1168.1	-	-	-	-	-	-	nd	nd	nd	nd	nd	nd	nd

^aValues reported are the average of 3 independent experiments.

^b- indicates 50% neutralization not achieved at the highest MAb concentration tested, 25μg/ml.

^cValues are from Saunders, et al. 2005.

^dnd: not done.