Table 1.
Incubation time (min) | Mean concentration ± SD (pmol/dish)a) | ||
Ciclesonide | des-CIC | des-CIC-oleateb) | |
3 | 15.04 ± 2.48 | 0.41 ± 0.05 | 0.00 ± 0.00 |
5 | 17.86 ± 2.30 | 0.33 ± 0.19 | 0.00 ± 0.00 |
10 | 36.63 ± 23.48 | 0.67 ± 0.13 | 0.02 ± 0.05 |
20 | 34.22 ± 9.15 | 0.97 ± 0.14 | 0.12 ± 0.07 |
30 | 48.21 ± 5.19 | 1.72 ± 0.14 | 0.40 ± 0.06 |
a) 5 dishes per time point
b) Conjugates of des-CIC with palmitic acid were almost undetectable.