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. Author manuscript; available in PMC: 2008 Oct 1.
Published in final edited form as: Gastroenterology. 2007 Jul 12;133(4):1188–1197. doi: 10.1053/j.gastro.2007.07.010

Figure 5. Relative Th2 skewing associated with colitis in WKO mice.

Figure 5

(A) WKO LP cells secrete markedly elevated levels of IL-4 and IL-13 as well as IFN-γ, TNF-α, and IL-2 with a decrease in IL-6. Results shown are means ± SEM pooling from two to four experiments, *p < 0.05 between WT and WKO stimulated with P+I. (B) Only IL-4 and IL-10 are mildly elevated in WKO MLN compared to WT. Results shown are means ± SEM pooling from two to four experiments, *p<0.05 between WT and WKO stimulated with P+I. (C) Shown are representative sections of two independent experiments of WT (left panel, objective: 10x) and inflamed (5-month-old) WKO (right panel, objective: 10x; inset, objective: 40x) colonic sections stained for IL-4 by immunohistochemistry. US = unstimulated; P+I = stimulated with PMA and ionomycin.