(A) WKO LP cells secrete markedly elevated levels of IL-4 and IL-13 as well as IFN-γ, TNF-α, and IL-2 with a decrease in IL-6. Results shown are means ± SEM pooling from two to four experiments, *p < 0.05 between WT and WKO stimulated with P+I. (B) Only IL-4 and IL-10 are mildly elevated in WKO MLN compared to WT. Results shown are means ± SEM pooling from two to four experiments, *p<0.05 between WT and WKO stimulated with P+I. (C) Shown are representative sections of two independent experiments of WT (left panel, objective: 10x) and inflamed (5-month-old) WKO (right panel, objective: 10x; inset, objective: 40x) colonic sections stained for IL-4 by immunohistochemistry. US = unstimulated; P+I = stimulated with PMA and ionomycin.