Table 1. LD90 and MBC values for DEFA1 against different micro-organisms.
LD90 and MBC values are defined as the lethal dose of DEFA1 that killed 90% (LD90) or 99.9% (MBC) of the target organisms. The highest peptide concentration tested was 6.1 μM.*, no killing detected at the indicated concentration.
| Test organism | Gram stain reaction | LD90 (μM) | MBC (μM) |
|---|---|---|---|
| E. coli A.T.C.C. 11775 | − | 0.2 | 0.4 |
| E. coli A.T.C.C. 25922 | − | 0.2 | 0.4 |
| E. coli A.T.C.C. 35218 | − | 0.05 | 0.4 |
| E. coli D31 | − | 0.4 | 0.8 |
| K. pneumoniae A.T.C.C. 13883 | − | 3 | >6.1* |
| Eb. cloacae A.T.C.C. 13047 | − | 6.1 | >6.1* |
| P. aeruginosa AT.C.C. 10145 | − | 3 | >6.1* |
| P. aeruginosa A.T.C.C. 11440 | − | 1.5 | 3 |
| B. cepacia A.T.C.C. 25416 | − | >6.1* | >6.1* |
| Staph. aureus A.T.C.C. 6538 | + | 0.4 | 0.8 |
| Staph. aureus A.T.C.C. 12600 | + | 0.4 | 1.5 |
| Staph. epidermidis A.T.C.C. 14990 | + | 0.8 | 1.5 |
| Ec. faecalis A.T.C.C. 29212 | + | 0.2 | 6.1 |
| Ec. faecalis PEG 205 (wild-type) | + | 0.4 | 3 |
| Strep. pyogenes A.T.C.C. 12344 | + | 0.8 | 0.8 |
| Bac. megaterium A.T.C.C. 14581 | + | 0.05 | 0.2 |
| C. albicans A.T.C.C. 24433 | 0.8 | 0.8 |