Figure 5. Cardiac expression of fatty acid-responsive genes involved in fatty acid futile cycling are increased to a greater extent by high fat diet compared with Western diet feeding.
mRNA expression of pparα (A), ucp3 (B), cte1 (C), mte1 (D), pdhk4 (E) and glut4 (F) in the hearts of rats fed on low fat, Western or high fat diet in the acute (AT), short (ST), intermediate (IT) and long term (LT). Values are means±S.E.M. for 12–16 independent experiments per group. Closed squares (■) represent low fat diet-fed rats, closed circles (●) represent Western diet-fed rats and closed triangles (▲) represent high fat diet-fed rats. *, P<0.05, **, P<0.01 and ***, P<0.001 versus low fat at the same age. $, P<0.05, $$, P<0.01 and $$$, P<0.001 compared with Western at the same age.