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. 2007 Apr 26;176(1):10–19. doi: 10.1164/rccm.200702-270OC

Figure 1.

Figure 1.

Airway function and inflammation is impaired in Arhgef1−/− mice in response to ovalbumin (OVA) systemic sensitization and subsequent airway challenge. (A) Lung resistance (Rl) and (B) dynamic compliance of wild-type (WT) and Arhgef1−/− mice in response to increasing concentrations of aerosolized methacholine after sensitization and challenge (SC) or challenge only (C). Symbols represent the geometric mean and error bars show SEM. WT C, n = 7; WT SC, n = 10; Arhgef1−/− C, n = 7; Arhgef1−/− SC, n = 4). *p < 0.05 for WT SC compared with Arhgef1−/− SC; #p < 0.05 for Arhgef1−/− SC compared with challenged only. (C) Leukocyte numbers and (D) cytokine levels in bronchoalveolar lavage (BAL) from sensitized and challenged or challenged-only WT and Arhgef1−/− mice. *p < 0.05.