TABLE 4.
COMPARISON OF GENES WITH SIGNIFICANT SINGLE-NUCLEOTIDE POLYMORPHISM ASSOCIATION FOR COMPUTED TOMOGRAPHY DENSITOMETRY VERSUS RADIOLOGIST SCORING FOR EMPHYSEMA DISTRIBUTION
| Densitometry Distribution of Emphysema*
|
NETT Radiologist Score Emphysema Distribution*
|
||||
|---|---|---|---|---|---|
| Gene | SNP | B (SE)† | p Value | B (SE)† | p Value |
| GSTP1 | rs947894 | −5.0 (1.5) | 0.001 | −0.08 (0.04) | 0.034 |
| EPHX1 | rs2234922 | −5.9 (2.1) | 0.005 | −0.14 (0.05) | 0.010 |
| rs1051741 | −5.5 (2.6) | 0.034 | — | — | |
| rs2260863 | 4.2 (1.8) | 0.016 | — | — | |
| rs360063 | 3.2 (1.6) | 0.049 | — | — | |
| MMP1 | rs1799750 | 4.1 (1.7) | 0.016 | — | — |
| TGFB1 | rs1800469 | — | — | 0.11 (0.04) | 0.013 |
| rs1982073 | — | — | 0.10 (0.04) | 0.020 | |
| rs2241712 | — | — | 0.09 (0.04) | 0.032 | |
| SERPINE2 | rs1371028 | — | — | 0.14 (0.07) | 0.046 |
| SFTPD | rs721917 | — | — | 0.08 (0.04) | 0.046 |
Definition of abbreviations: NETT = National Emphysema Treatment Trial; SNP = single-nucleotide polymorphism.
Dashes indicate p > 0.05. Significant results based on both densitometry and radiologist scores are in bold.
*
Mean (SD) and [range] of densitometry distribution of emphysema percent = 14 (± 19) [−33 to 64] and of radiologist score emphysema distribution = 0.38 (± 0.50) [−1.2 to 2.4].
†
Only regressions with p ⩽ 0.05 are shown; all regression models include covariates for genotype, age, sex, pack-years of smoking and FEV1.