Figure 6. Effects of lactate on mice skeletal muscle glucose consumption.

Glucose consumption was assessed in the absence (A) or the presence (B) of 100 nM insulin. Values are means±S.E.M. for at least four independent experiments. *P<0.05 compared with the respective control in the absence of lactate and in the presence of 4.5 or 15 mM glucose. The absolute rates for glucose consumption are 0.32±0.03 mmol·g⁻¹·h⁻¹ in the presence of 4.5 mM glucose and 0.36±0.03 mmol·g⁻¹·h⁻¹ in the presence of 15 mM glucose, in the absence of insulin, and 0.78±0.06 mmol·g⁻¹·h⁻¹ in the presence of 4.5 mM glucose and 0.86±0.08 mmol·g⁻¹·h⁻¹ in the presence of 15 mM glucose, in the presence of 100 nM insulin.