Table 1. Comparison of cholesterol metabolism in mice and fruitflies.
Data sources were as follows: NPC1L1− mice [2,19]; NPC1− mice: the present study and [24–26]; dNPC1b− and dNPC1a− fruitflies: [15]. Abbreviation: N.D., not determined.
| Functional protein | Cholesterol uptake | Cholesterol biosynthesis | |||
|---|---|---|---|---|---|
| NPC1L1 (dNPC1b) | NPC1 (dNPC1a) | Mouse | Fruitfly | Mouse | Fruifly |
| + | + | Normal | Normal | Normal | None |
| − | + | ↓↓↓ | ↓↓↓ | ↑↑ | None |
| + | − | Normal | ↑↑ | ↑↑ | None |
| − | − | ↓↓↓* | ↓ | N.D. | None |
* Pharmacological inhibition of NPC1L1 using ezetimibe.