Figure 5.

Model for the role of Akt in IL-2 signaling. Signals transduced from the S region of the IL-2Rβ activate the PI3-kinase and Akt and induce Bcl-2 and c-myc expression. These signals are sufficient to inhibit apoptosis and to stimulate progression through the cell cycle. Because catalytically active Akt mutants fully replace these IL-2 signals, we conclude that they are transduced via Akt.