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. 2007 Nov 15;21(22):2976–2994. doi: 10.1101/gad.1588907

Figure 4.

Figure 4.

Vesicular trafficking to the lysosome and protein sorting is required for decreased insulin/IGF1 signaling to extend life span. daf-2(e1370) (circles), pdk-1(sa680) (triangles), or daf-2(e1370);daf-16(mgDf47) (squares) animals on dsRNA to empty vector control (white symbols, A–R) or to daf-16 (A), CD4.4 (B), C27F2.5 (C), F17C11.8 (D), Y65B4A.3 (E), T27F7.1 (F), rab-7 (G), M57.2 (H), C31H2.1 (I), gdi-1 (J), vps-16 (K), B0303.9 (L), wwp-1 (M), vrk-1 (N), ptr-23 (O), cua-1 (P), Y47G6A.18 (Q), and F30A10.6 (R) (black symbols). (S) Relative life span (to empty vector control) of daf-2(e1370) (X-axis) versus pdk-1(sa680) (Y-axis) for each endocytosis gene inactivation. Empty vector control is indicated by a black arrow, daf-16 RNAi is indicated by a gray circle and gray arrow. (T) Relative life span (to empty vector control) of daf-2(e1370) (X-axis) versus daf-2(e1370);daf-16(mgDf47) (Y-axis) for each endocytosis gene inactivation. Empty vector control is indicated by a black arrow, daf-16 RNAi is indicated by a gray circle and gray arrow.