Comparison of the deduced amino acid sequences of human ELL2 and ELL. ELL2 residues 11–640 are from the sequence of a DNA fragment obtained by PCR amplification of a human fetal heart cDNA library. Residues 1–10 are from Human Genome Sciences ESTs HNFD055 and HNEAK22 and from an EST in the GenBank database (accession number W94585W94585). Identical amino acids are shown in white letters on a black background; similar amino acids (A, S, T, P; D, E, N, Q; H, R, K; I, L, M, V; F, Y, W) are shown in black letters on a gray background. Conserved regions 1, 2, and 3 are indicated by single, double, and triple underlines, respectively.