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Coexpression of GRIP1 increases the transactivation by RXR in response to 9c-RA ligand. Yeast transformants expressing RXRα, RXRβ, or RXRγ alone or with GRIP1 and containing a β-gal reporter with a site A1 enhancer element sequence of the apolipoprotein gene (ApoA1 × 1) were grown for 16 hr in the presence of no ligand (open bars) or 1 μM 9c-RA (shaded bars) and β-gal was assayed.
