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Response of calcium transient to agonist-bearing media. As the perfusion rate (and shear stress) increases, the response accelerates. The influence is significant at low shear stresses (<0.5 N/m2), where mass transfer is rate-limiting. Above 0.5 N/m2, perfusion rate has diminishing effects because receptor dynamics are rate-limiting (C0 = 1 unit per ml, Caex = 0).
