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. 1997 Apr 15;94(8):3753–3758. doi: 10.1073/pnas.94.8.3753

Figure 4.

Figure 4

Effect of oxysterols on caveolin mRNA levels. Conditions are as described in the legend to Fig. 1. Cells equilibrated with 7% (vol/vol) plasma (lane 1) were transferred to medium containing 80% (vol/vol) plasma (lane 2); 80% (vol/vol) plasma + 10% (wt/wt) CαEP (lane 3); 80% plasma + 10% CβEP (lane 4); 80% plasma + 10% 7-KC (lane 5); or 80% plasma + 10% 7αOH-C (lane 6). Caveolin mRNA was increased 3.6-fold by 80% (vol/vol) plasma. mRNA levels were 0.46, 0.40, 0.36, and 0.34 of this level in the presence 10% (wt/wt) CαEP, CβEP, 7-KC, and 7αOH-FC, respectively. FC efflux rates were (3.9 ± 0.2)-fold increased by 80% (vol/vol) plasma, and were 0.54, 0.50, 0.46, and 0.46 of this increased level in the presence of the same oxysterols.