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Disruption of the Stat3 gene. (a) The structure of the targeting vector and the mutated Stat3 gene. Restriction sites were: E, EcoRI; H, HindIII. (b) Southern blot analysis of the offspring from intercross of Stat3+/− mice. (c) PCR analysis of the microdissected embryonic tissues at E6.5. Primers a and b were used for detection of the wild-type allele, and a and c were used for the mutated allele.
