Figure 2.

Histological analysis of wild-type and Stat3^−/− embryos. Wild-type embryos (a, c, e, and g) and Stat3^−/− embryos (b, d, f, and h) were dissected at E6.0 (a and b), E6.5 (c and d), E7.0 (e and f), and E7.5 (g and h). Note the rapid degeneration of Stat3^−/− embryos from E6.5 to E7.5. Stat3^−/− embryos formed a two-layered egg cylinder at E6.0 (b) but were degenerated rapidly and resorbed completely by E7.5 (d, f, and h). ee, embryonic ectoderm; m, mesoderm; pac, proamniotic cavity; and ve, visceral endoderm. [Bars = 40 μm (a–f) and 100 μm (g and h).]