Figure 2.

Summary of the chromosomal imbalances detected in four HPV-immortalized keratinocyte cell lines at different time points. Vertical lines on the left of chromosome ideograms indicate loss of genetic material; vertical lines on the right indicate gain of genetic material. Each line is presented by a color as indicated at the bottom. Chromosomal imbalances were not found at the first time point analyzed; imbalances found at the second, third, fourth, and fifth time points are drawn with lines of increasing thickness as indicated at the bottom. Interrupted lines indicate ratio values close to, but not reaching, the diagnostic threshold, possibly because of the presence of a subclone carrying this chromosomal imbalance (see text). ∗, The distal part of chromosome 1p and the chromosome 19 are labeled with asterisks because imbalances found in these two regions were not scored for reasons mentioned in Materials and Methods.