Figure 3.

Sensorimotor performance of Tg-CuZnSOD and control mice. (Left) The rope grip test was conducted as described in Material and Methods. Four-month-old mice were allowed to grip with their front legs a 2-mm-thick horizontal tight rope placed 80 cm above the ground (a and c), and the time elapsed until the mice raised their hind legs to grip the rope (b and d) was measured. If the mouse gripped the rope by both hind legs within 60 sec and kept the grip for at least 10 sec, the mouse was recorded as a success. (Right) Each group contained 5–10 mice, all of which were analyzed twice on two different days, each time with three repetitions. Numbers indicate the average of total repetitions. Results are expressed as the mean ± SEM. Four-month-old Tg-CuZnSOD mice (open bars) and PQ-treated (hatched bars) differed significantly from control mice (★, P = 0.01; ♦, P = 0.03; ▴, P = 0.05). P values were determined by Student’s t test.