Table 1.

Allelic dosage of the partial tandem duplication of ALL1 in AML blasts

UPN	Karyotype*	ALL1 partial duplication*	Copies of ALL1 exon 18†	Copies of ALL1 exon 5†
C‡	46,XY	N/A	2	2
23	47,XX,+11	Exon 2–exon 6	2.92  ±  0.026	3.86  ±  0.071
56	47,XY,+11	Exon 4a–exon 6	2.99  ±  0.035	3.83  ±  0.075
108	47,XY,+11	Exon 2–exon 8	2.98  ±  0.024	3.89  ±  0.051
144	46,XX	Exon 2–exon 8	2.01  ±  0.023	3.05  ±  0.030
211	46,XX	Exon 2–exon 6	2.01  ±  0.003	3.13  ±  0.006

^*As reported in ref. 11 for UPNs 23, 56, and 108, and ref. 12 for UPNs 144 and 211. 

^†As quantitated by phosphorimage analysis, relative to one-half of the signal intensity measured from the same amount of DNA obtained from normal diploid cells (C) hybridized to the same probe. 

^‡C, control of diploid cells from a normal donor; N/A, not applicable.