Figure 2.

Injection of parasites into an established transplant results in a massive infiltration of CD8⁺ T cells. Established heart transplant 14 days after injection of parasites has virtually all of the muscle tissue displaced by inflammatory cells that stain positively (yellow/brown precipitate) for the CD8 molecule (A and B). The native heart of the same animal also exhibits a CD8⁺ cell-dominated inflammation (C). The parasite-injected transplanted heart contains a large number of cells which are producing tumor necrosis factor α (D). (A, ×63; B–D, ×250.)