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Survival of leukemic SCID mice treated with different doses of thioate or amidate c-myc AS-ODNs. Mice injected with 106 HL-60 cells were treated intravenously 7 days later with 900, 300, or 100 μg/day for 6 consecutive days with □, c-myc phosphorothioate MM-ODN; ▵, c-myc phosphoramidate MM-ODN; ▪, c-myc phosphorothioate AS-ODN; or ▴, c-myc phosphoramidate AS-ODN. Control mice (○) received diluent only. Five mice were included in each group.
