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. Author manuscript; available in PMC: 2008 Oct 1.
Published in final edited form as: Pain. 2007 Sep 4;131(3):243–257. doi: 10.1016/j.pain.2007.07.026

Figure 4.

Figure 4

While the L858H mutation increases firing frequency in DRG neurons and decreases firing frequency in SCG neurons, coexpression of Nav1.8 channels rescues electrogenic properties in SCG neurons. A, Representative DRG neuron expressing wild-type Nav1.7 fires a single action potential in response to a 100 pA stimulus. B, Representative DRG neuron expressing L858H fires five action potentials in response to a 100 pA stimulus. C, Representative SCG neuron expressing WT Nav1.7 fires six action potentials in response to a 40 pA stimulus. D, Representative SCG neuron expressing L858H fires only two action potentials in response to a 100 pA stimulus. E, Action potentials recorded from representative SCG neurons transfected with wild-type Nav1.7, L858H, and L858H plus Nav1.8 channels. When Nav1.8 was coexpressed with L858H, current threshold and action potential overshoot were restored. Adapted from Rush et al., 2006a. © 2006 National Academy of Sciences, USA.