Figure 1.

Isolation of a full-length KVLQT1 cDNA. (a) A full-length human KVLQT1 cDNA (3,157 bp) was derived from two overlapping λgt11 cDNA clones. S1–S6, transmembrane domains 1 through 6; P, pore-forming domain; ORF, open-reading frame; 5′ UTR and 3′ UTR, 5′ and 3′ untranslated regions, respectively. The figure is not drawn to scale. (b) Amino acid sequence of KvLQT1 and comparison to a Genefinder-predicted potassium channel-like protein, C25B8.2, from C. elegans (GenBank database accession no. U41556U41556). | denotes amino acid sequence identity; : denotes a conservative amino acid substitution.