Table 1.
Tissue levels of radioactivity in pregnant mdr1b (+/+) and (−/−) mice 4 hr after i.v. injection of [3H]digoxin (1 mg/kg)
| Tissue | mdr1b (+/+) | mdr1b (−/−) | Ratio (−/−):(+/+) |
|---|---|---|---|
| Brain | 13.5 ± 2.4 | 18.7 ± 3.8 | 1.4 |
| Muscle | 397 ± 47 | 288 ± 24 | 0.7 |
| Heart | 235 ± 55 | 243 ± 18 | 1.0 |
| Kidney | 319 ± 77 | 361 ± 82 | 1.1 |
| Liver | 727 ± 263 | 766 ± 119 | 1.1 |
| Lung | 176 ± 56 | 175 ± 14 | 1.0 |
| Spleen | 118 ± 35 | 120 ± 15 | 1.0 |
| Colon | 604 ± 116 | 574 ±128 | 1.0 |
| Uterus | 318 ± 89 | 219 ± 60 | 0.7 |
| Placenta | 322 ± 108 | 258 ± 43 | 0.8 |
| Fetuses | 105 ± 8 | 109 ± 6 | 1.0 |
| Plasma | 689 ± 343 | 764 ± 81 | 1.1 |
Results are means ± SD in nanograms per gram tissue ([3H]digoxin equivalent). Three pregnant mice were analyzed in each group. All fetuses of each mother were pooled.