Figure 1.

Schematic presentation of cleavage sites on APP and two types of mutations implicated in early-onset familial AD. The amino acid sequence of βA4 (1–42) is underlined (one-letter code for amino acids). The major cleavage sites are indicated by arrows on the top of the sequence; the two mutations, βA4 and p3 fragments, and approximate location of the epitopes of W0-2, G2-10, and G2-11 antibodies are shown below the sequence.