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. 1997 Apr 15;94(8):4161–4166. doi: 10.1073/pnas.94.8.4161

Figure 5.

Figure 5

Most synapses in the neocortex pathway have a relatively high probability of release. (A) Normalized NMDA receptor-mediated responses (amplitude) in the neocortex (•) and in the hippocampus (○) pathways as paired stimuli [50 msec interstimulus interval (ISI)] were delivered at 0.1 Hz before and in the presence of MK-801 (n = 7 per group; mean ± SEM). (B) MK-801 increases the facilitation ratio in both pathways. Percentage change of the NMDA receptor-mediated response to the second stimulus in a pair with respect to the first as a function of the pair number (results are from experiments in A), before and in the presence of MK-801 (n = 7 per group; mean ± SEM). (C) Percentage change of the NMDA receptor-mediated response to the second stimulus in a pair with respect to the first as a function of the normalized amplitude of the NMDA receptor-mediated response in hippocampus (left axis, •) and in neocortex (right axis, ○). Arrows indicate the amplitude of NMDA receptor-mediated response when facilitation reached its maximum plateau level for hippocampus and neocortex.