Table 2.

Effect of SP antagonist RP-67,580 and enantiomer RP-68,651 on trypanosome-induced meningoencephalitis

Treatment regimen	Neuropathological grading
Trypanosome + salinea (n = 25)	3.3  ±  0.17
Trypanosome + RP-67,580b (n = 26)	2.4  ±  0.18
Trypanosome + RP-67,580c (n = 35)	2.4  ±  0.17
Trypanosome + RP-68,651d (n = 5)	3.5  ±  0.22

Brain tissue from trypanosome infected animals exposed to saline or RP-67,580 treatment were processed as described. The severity of the neuropathology was graded by a score of 0–4. Data are expressed as means ± SE for each group. n, Number of mice tested; a, saline control; b, combined results of initial three experiments; c, combined results of all four experiments; d, enantiomer control. a vs. b, P = 0.0002; a vs. c, P = 0.0001; a vs. d, P = 0.38.