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. 1997 Apr 15;94(8):4193–4198. doi: 10.1073/pnas.94.8.4193

Figure 3.

Figure 3

Effect of l-NAME and l-NNA on ACh-induced hyperpolarization, relaxation, and NO release. ACh-evoked relaxations (open symbols) and hyperpolarizations (filled symbols) recorded from arterial rings contracted and depolarized with phenylephrine under control conditions (circles), after treatment with l-NAME (3 × 10−5 M; squares), or after treatment with l-NAME (3 × 10−5 M) and l-NNA (3 × 10−4 M; triangles) are shown in a. (b) Close correlation between the release of NO measured with the porphyrinic microsensor from rabbit carotid arteries caused by ACh (3 × 10−6 M) under control conditions or after treatment with the same concentrations of l-NAME, or l-NAME combined with l-NNA and the maximal relaxation (filled circles) or hyperpolarization (open circles). (c) Close correlation between the maximal relaxation (filled circles) or hyperpolarization (open circles) to ACh (3 × 10−6 M) and the cumulative release of nitrite caused by the concentration response to ACh (10−8 to 3 × 10−6 M) under control conditions or after treatment with l-NAME alone or with the combination of l-NAME and l-NNA.