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. 2007 Oct 30;4(5):267–277. doi: 10.7150/ijms.4.267

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Chemical structure of Clamp-PNA-BioShuttle phNIS-IRES-EGFP. The transport molecule consists of: A. Amphiphilic transmembrane transport module responsible for the transport across outer cellular membranes into the cytoplasm. B. Address sequence peptide which potentiates the active transport of cargos into cell nuclei using RAN-mediated mechanisms. C. Hybridization-site harbouring two identical PNA-sequences against ORI-sequences of the phNIS-IRES-EGFP, connected with lysine via a duplex glycine spacer.