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. Author manuscript; available in PMC: 2007 Nov 5.
Published in final edited form as: Brain Behav Immun. 2007 Feb 9;21(5):581–591. doi: 10.1016/j.bbi.2006.12.003

Figure 2. ddC induced neuropathic pain is accompanied by nerve pathology.

Figure 2

The sciatic nerve was removed and analyzed for resulting pathology three days after a single i.p injection of ddC. A & B) Low and high power photomicrographs of the sciatic nerve from a vehicle-treated rat. C & D) Low and high power photomicrographs of a PID3 sciatic nerve after a single i.p. injection of ddC. Note the increased myelin sheath thickness of the largest diameter nerve fibers in the sciatic nerve. The mean diameter of normal and pathological axons did not differ, suggesting that the increase in myelin area diminishes the area of the axon cytoplasm. Also observed is a degeneration of the Remak bundles associated with unmyelinated axons as well (see arrows). Scale bar for A and C is 20μm; B and D is 5μm.