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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Brain Behav Immun. 2006 Dec 15;21(5):686–698. doi: 10.1016/j.bbi.2006.10.012

Fig. 6.

Fig. 6

Intrathecal IL-10 gene therapy partially reverses mechanical allodynia induced by a higher dose of paclitaxel. Rats received i.p. injections of paclitaxel (cumulative dose 8 mg/kg) or vehicle on alternate days, and two i.t. injections of pDNA-IL-10 (100 and 25 μg), pDNA-Control (100 and 25 μg), or vehicle were given 5 weeks after the first paclitaxel injection, 3 days apart (indicated by the arrows). Low-threshold mechanical sensitivity was assessed by the von Frey test, before (baseline, BL) and weekly after the first paclitaxel or vehicle injection, and up to 43 days after the first i.t. injection. A third i.t. injection of pDNA-IL-10 (25 μg), pDNA-Control (25 μg), or vehicle was given on Day 43 after the first i.t injection (indicated by the arrow), and von Frey responses were subsequently assessed up to 66 days later. Data represent means ± SE.