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Experimental design
| Exp. # | n/group | Paclitaxel dose (cumulative) | Intrathecal treatment | Day(s) of injection (Dose in μg) |
|---|---|---|---|---|
| 1 | 3-4 | 4 or 8 mg/kg | - | - |
| 2 | 4 | 8 mg/kg | - | - |
| 3 | 6-7 | 4 mg/kg | IL-1ra or vehicle | 18 (150) |
| 4 | 5 | 4 mg/kg | pDNA-IL-10 or PBS | 35 (100), 38 (25) |
| 5 | 5-6 | 4 mg/kg | pDNA-IL-10, pDNA-Control, or PBS | 12 (100), 15 (25) |
| 6 | 5 | 8 mg/kg | pDNA-IL-10, pDNA-Control, or PBS | 35 (100), 38 (25), 78(25) |
| 7 | 4-8 | 4 mg/kg | pDNA-IL-10, pDNA-Control, or PBS | 18 (100), 21 (25) |
