Table I.
Decreases in muscle mass but normal fiber number in Pax7lacZ/lacZ muscle
|
|
Body mass (g)
|
|
TA mass (mg)
|
EDL fiber number |
Soleus fiber number |
EDL nuclei/ fiber |
Soleus nuclei/ fiber |
|
|---|---|---|---|---|---|---|---|---|
| P0 | P3 | P10 | P10 | P10 | P10 | P100 | P100 | |
| Pax7 + / + | 1.3 ± 0.05 (n = 9) |
3.1 ± 0.1 (n = 11) |
7.1 ± 0.3 (n = 11) |
5.6 ± 0.6 (n = 8) |
947 ± 40 (n = 5) |
897 ± 107 (n = 3) |
ND | ND |
| Pax7 + /lacZ | 1.2 ± 0.04 (n = 10) |
3.0 ± 0.1 (n = 15) |
6.8 ± 0.3 (n = 13) |
5.4 ± 0.3 (n = 10) |
ND | ND | 227 ± 5 (n = 20) |
402 ± 8 (n =20) |
| Pax7lacZ/lacZ | 1.3 ± 0.05 (n = 5) |
1.9 ± 0.1a (n = 9) | 3.0 ± 0.3a (n = 8) | 1.6 ± 0.3a (n = 6) | 1,028 ± 61 (n = 5) |
865 ± 250 (n = 3) |
142 ± 6a (n = 20) | 170 ± 8a (n = 10) |
a
Significant at
P < 0.01.