Table 1.
Analysis of LysoTracker-positive granule movement in BMMCs
| Genotype | Average velocity (μm/s) | Motile granules(%) | Displacement (μm) | |||
|---|---|---|---|---|---|---|
| Number studied | 0.5–1.0 | 1.0–1.5 | >1.5 | |||
| Double heterozygote | 0.16 ± 0.06 (n = 408) | 21.3 | 87 | 90.8% | 8.0% | 1.2% |
| Double KO | 0.15 ± 0.07 (n = 521) | 12.7 | 66 | 78.8% | 10.6% | 10.6% |
| Double KO + nocodazole | 0.05 ± 0.03 | 2.7 | ND | ND | ND | ND |
ND, not determined. The LysoTracker-positive granule movements were analyzed as described under Materials and Methods. Motile granules are defined as ones with displacement exceeding 0.5 μm and average velocity exceeding 0.1 μm per second.