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. 2007 Jan 1;176(1):11–17. doi: 10.1083/jcb.200605099

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — Dominant-negative FEZ1 disrupts Kinesin-1 transport of JIP1. (A–D) Differentiated CAD cells expressing myc-FEZ1 (A), myc-FEZ1(1–230; B), or myc-FEZ1(1–308; C) or untransfected cells (D) were double labeled for the myc tag and endogenous JIP1 protein. Arrows indicate tips of neurites in transfected cells. Bar, 10 μm. (E) Quantification of JIP1 tip staining. n values in parentheses indicate the number of cells. Error bars represent SD. *, P ≈ 0.01; **, P < 0.001 compared with untransfected cells.