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. 2007 Jan 1;176(1):35–42. doi: 10.1083/jcb.200605135

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — The activation of peripheral RhoA–ROCK–MLC2 signaling in Smurf1-silenced cells is responsible for the loss of lamellipodia. (a) Control or Smurf1-silenced MDAMB-231 cells were stained for F-actin; tat-C3 was added for 24 h. (b) Smurf1- and/or RhoA-silenced MDAMB-231 cells were stained for F-actin and p(S19)-MLC2. (c) Control or Smurf1-silenced MDAMB-231 cells were stained for F-actin, RhoA, and p(S19)-MLC2; 25 nM tat-C3 or 5 μM Y-27632 was added for 24 h. (d) Control or Smurf1-silenced MDAMB-231 cells were stained for F-actin; blebbistatin was added for 60 min.