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. 2006 Jan 30;172(3):335–346. doi: 10.1083/jcb.200507162

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Copyright © 2006, The Rockefeller University Press

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Figure 7. — A schematic model for mitotic exit. In the presence of spindle positioning defects (A), Bub2-dependent Bfa1 retention at both SPBs prevents mitotic exit by inhibiting Tem1. When anaphase takes place correctly and one SPB crosses the bud neck (B), a signal is sent to the mother-bound SPB, where the Bub2–Bfa1 complex is removed through the action of Bub2 GAP activity, thus leading to Tem1 activation at this pole. This helps trigger mitotic exit, together with Bfa1 inhibition by Cdc5, presumably at the bud-directed SPB, and with increased Tem1 loading on the same SPB.