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. 2006 Jan 30;172(3):383–393. doi: 10.1083/jcb.200507057

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Identification of Derlin-2 and -3. (A) The levels of CGI-101, BiP, and β-actin mRNA are determined by microarray analysis in HeLa cells treated with or without 2 μg/ml tunicamycin for 8 h. Fold induction was determined, with the means from six independent experiments presented with SDs (error bars). CGI-101 is identical to Derlin-2. (B) Hydropathy plots of human Derlin-2 (CGI-101), -3 (FLJ43842), and -1 are shown. Hydrophobicity and hydrophilicity (expressed by positive and negative numbers, respectively) of the amino acid sequences of three human Derlins were obtained according to the method of Kyte and Doolittle (1982). Black bars mark hydrophobic regions that span the membrane. (C) Amino acid sequence alignment of human Derlin-2, Derlin-3 tv1, Derlin-3 tv2, Derlin-1, and yeast Der1p is shown. Identical amino acids are indicated by white letters in black boxes. Two transcriptional variants for Derlin-3 are deposited in the data bank. Derlin-3 tv1 lacks the 30 COOH-terminal amino acids present in Derlin-3 tv2.