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. 2006 Jan 30;172(3):423–432. doi: 10.1083/jcb.200505175

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Copyright © 2006, The Rockefeller University Press

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Figure 10. — Signaling pathways in floating collagen matrix contraction. Model showing convergence of PDGF and LPA signaling on PAK1 and cofilin1, cell ruffling, and collagen matrix contraction. Rho kinase cooperates with PAK1 for PDGF-stimulated contraction, whereas mDia1 cooperates with PAK1 for LPA-stimulated contraction. Rho kinase also is required for LPA-stimulated retraction of dendritic extensions.