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. 2006 Feb 13;172(4):529–540. doi: 10.1083/jcb.200507081

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Combined Bub3 and Rae1 haploinsufficiency reduces lifespan. (A–D) Representative photographs of wild-type and Bub3^+/−/Rae1^+/− mice at 5 (A and B) and 27 mo (C and D). These animals were not moribund at the time of the picture. Note the overt cataract, severe lordokyphosis, and cachetic appearance of the 27-mo-old Bub3^+/−/Rae1^+/− mouse pictured in D. (E) Overall survival curves for wild-type, Bub3^+/−, Rae1^+/−, and Bub3^+/−/Rae1^+/− mice. The curve marked with an asterisk is significantly different from that of wild-type mice using a log-rank test. We note that the lifespan of Bub3^+/− and Rae1^+/− mice is not statistically different from that of Bub3^+/−/Rae1^+/− mice.