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. 2006 Feb 13;172(4):529–540. doi: 10.1083/jcb.200507081

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Bub3^+/−/Rae1^+/− mice develop spontaneous tumors at normal rates despite severe aneuploidy. (A) Spontaneous tumor incidence, latency, and spectrum of wild-type and Bub3^+/−/Rae1^+/− mice. Upon biopsy of moribund animals, all tissues were screened for tumors. Tumorous tissues were collected and processed for histological evaluation. (B) Tumor-free survival curves of wild-type, Bub3^+/−, Rae1^+/−, and Bub3^+/−/Rae1^+/− mice.