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. 2006 Feb 13;172(4):529–540. doi: 10.1083/jcb.200507081

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Copyright © 2006, The Rockefeller University Press

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Figure 3. — Combined Bub3 and Rae1 haploinsufficiency accelerates cataract formation. (A) Cataract incidence of wild-type, Bub3^+/−, Rae1^+/−, and Bub3^+/−/Rae1^+/− mice as detected by the use of slit light after dilating the eyes. The asterisk indicates that the curve is statistically different from that of wild-type mice using a log-rank test. (B) Overt cataract detected in a 15-mo-old Bub3^+/−/Rae1^+/− mouse. (C) Cross section of a cataractous lens from a 15-mo-old Bub3^+/−/Rae1^+/− mouse stained with hematoxylin and eosin. Note that the posterior portion of the eye has Morgagnian globules, whereas the inner portion has profound calcification. Bar, 1 mm.