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. 2006 Feb 27;172(5):719–731. doi: 10.1083/jcb.200510065

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Copyright © 2006, The Rockefeller University Press

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Figure 3. — IRS2 is required for clearance of mutant htt. (a) Representative images generated on the INCA 3000 of control (Ctrl; scramble + 2d dox), siRNA alone, and Dox + siIRS-2. (b) Quantification of percentage of control of the number of aggregates per cell for the three images. The presence of an effective siRNA against IRS-2 (si8H06) abolishes the clearance seen in the presence of dox. Complete quantitative results can be found in Fig 2.