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. 2006 Feb 27;172(5):771–782. doi: 10.1083/jcb.200512115

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Adhesion to ECM proteins is enhanced in zyxin-null fibroblasts, but integrin expression is unchanged. (A) Wild-type and zyxin-null fibroblasts were evaluated for adhesion to vitronectin, laminin, collagen IV, and fibronectin (5 μg/ml; 25 min). After removal of unattached cells, the adherent cells were fixed, stained with toluidine blue, and quantitated by absorbance at 620 nm. Data represent the mean ± SEM. n = 4. (B) GFP-zyxin reintroduced into zyxin−/− cells decreased the adhesion to laminin, relative to zyxin−/− cells. (C) Immunoblot analysis of wild-type and zyxin−/− fibroblasts for integrins α3, α5, αV, β1 and β3. Immortalized cell lines were used for adhesion assays. *, P < 0.05; **, P < 0.005.